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ATP SCIENCE CREATINE MONOHYDRATE
  • ATP SCIENCE CREATINE MONOHYDRATE

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CREATINE MONOHYDRATE AND MUSCLE GROWTH

Studies have concluded that there is an increase in muscle following resistance exercise training with creatine monohydrate administration in older adults.2  We have also previously reported that older adults show a significant increase in total muscle creatine following four months of creatine monohydrate supplementation at 5g per day. An increase in satellite cell number occurs in older adults in response to resistance exercise training, and creatine monohydrate has been shown to enhance satellite cell activation during resistance exercise training in younger men.3 Together, the aforementioned data found that creatine monohydrate may enhance the resistance exercise induced activation of satellite cells and contribute to the increase in muscle mass seen a well-designed study.4  The increase in muscle mass was due to creatine monohydrate given that the potentiation of the muscle gains seen in the research were similar to those previously reported studies using creatine monohydrate as a muscle stimulating agent.

How Creatine works in the muscles

Creatine is a substance found in muscle that combines with phosphate to form creatine phosphate. Creatine phosphate reacts with adenosine di-phosphate to regenerate adenosine tri-phosphate (ATP – stored energy) in working muscle. Dietary supplementation of creatine may increase the total creatine and creatine phosphate content of the muscle. Researchers have found that muscle creatine phosphate levels drop significantly after the performance of a 300 meter run, which lasts 30 to 40 s suggesting that the lack of creatine phosphate may somehow limit performance during intense, short term exercise.5

Thus, buffering of ATP by phosphocreatine extends the duration of activity possible and increasing creatine enhances endurance.

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